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On the other hand, supplementation with placebo or l-carnitine will not require alteration to usual care pathways (including use of any medications)

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& Knowles, J

In mammals, carnitine acts through the reversible esterification of its 3-hydroxyl group by fatty acyl-CoA esters with subsequent translocation of the acylcarnitines produced from one cellular compartment to another

Additionally, self-derived or foreign-derived particulates can be endocytosed by lysosomes, leading to membrane damage and further release of cathepsin B, another common upstream signal for NLRP3 activation (96)

A double-blind, placebo-controlled study