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In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

The PDX tumors used in this study include TM00096 (MDM2 high ) and TM00098 (MDM2 low ) from the Jackson Laboratory

doi:10.12688/f1000research.20510.1 Croce L, De Martinis L, Pinto S, et al

Specifically, on day 14, vessel counts were significantly higher in the TCC group at 5.35 0.81 than in the zinc oxide at 1.92 0.78 and control groups at 1.29 1.00

2) To more fully engage patients in their care, collecting patient reported outcomes at each visit

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