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[8]Haque AFMM, Rahman MA, et al

-KG is a key intermediate in the TCA cycle and an important cofactor for dioxygenases, including TET and JMJD histone demethylases

exogenous) remains unclear

However, while treatment of cells with the proteasome inhibitor MG-132 led to a strong accumulation of ATF-4 in cells grown in complete medium, there was no restoration of ATF-4 protein levels or expression of target gene products ASNS and PSAT in cells grown in -SG medium plus PH755 (Supplementary Figure 5a)