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However, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) caused by smoking are permanent

A., & Pennathur, A., et al

E-cigarettes pose many public health concerns: Most contain nicotine, which is highly addictive and adversely impacts brain development Not an FDA-approved quit aid May re-normalize smoking behaviors Youth use is rising rapidly There is no proof that the vapor is safe for the person vaping, or for those breathing in the secondhand vapor Little is known about their long-term effects Are e-cigarettes regulated by the Food and Drug Administration (FDA)

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NUDT1 hydrolyzes oxidized guanine in the nucleotide pool, thus preventing the misincorportation of 8-OH-dGTP opposite adenine during DNA replication, which produces A:TC:G transversion mutation ( see , Figure 2) [161, 162]