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Briggs Kimberly J, Koivunen P, Cao S, Backus Keriann M, Olenchock Benjamin A, Patel H, Zhang Q, Signoretti S, Gerfen Gary J, Richardson Andrea L, Witkiewicz Agnieszka K, Cravatt Benjamin F, Clardy J, Kaelin William G

however, it has 3 major limitations: a low success rate in reducing intrabody aggregation, insufficient correlation between the estimated net negative charge of intrabodies at pH 7.4 with experimentally determined stability, and a lack of in vivo validation for the targeting of endogenous proteins 4

Garca-Gutirrez M, Prez-Ortiz J, Gutirrez-Adn A, Manzanares J (2010) Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors: depression and CB2r