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Keep in mind, the S0 category could include substances that are not specifically indicated on the Prohibited List

10.1016/j.chembiol.2020.02.005 96 LiuP.FengY.LiH.ChenX.WangG.XuS.et al (2020b)

Nature 569 , 723728 (2019)

Exceptional safety margin No dependence or tolerance naturally occurring endogenous peptide Tolerability in clinical trials No tolerance develops with repeated doses No withdrawal symptoms upon stopping Peptide naturally present in the human body Research considerations Researcher's notes Outstanding safety profile for a bioactive peptide No serious adverse events were reported in the published studies

research shows the importance of B12 in other conditions like Parkinsons, MS and dementia but is underfunded

Results clearly showed that the tyrosine-nitration level was reduced in proportion to the molar ratios of GSSSG and LASSS relative to HGF, as revealed by the decrease in anti-nitroY mAb-positive HGF (60-kDa -chain and 90-kDa proform) normalized to total HGF -chain as a loading control, that was monitored by stripping with SDS-ME solution and re-probing the blot with anti-HGF -chain N-terminal domain mAb (Figure 1b,c, second and third rows)