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10.2174/1570159X22666231103085859 Summary Keywords deuterium, copper, histidine, amyloidogenic proteins, cardiolipin, mitochondrial dysfunction, neurodegeneration Citation Seneff S and Kyriakopoulos AM (2025) Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease

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In addition to the similarity of certain metabolic signaling pathways such as the Wnt/-catenin pathway, Heregulin-HER3-HER2 signaling and the EGFR/PI3K/Akt pathway, brain metastatic cancer cells also share certain metabolic characteristics with neuronal cells (152)

In addition, oxidative stress-related damage is positively related to genome instability, loss of sperm quality, and fertilization failure (2, 17)

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