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Distinct EV categories, for example, native EVs, bacterial OMVs, and EV-mimetics/hybrid systems, require tailored CMC protocols to address their unique risk profiles, including detoxification and residual DNA controls for OMVs, and stability/function validation for semi-synthetic platforms [37, 38]

Results: While clinical parameters alone showed limited predictive accuracy (40% accuracy, AUC 0.62), radiomics features demonstrated modest performance (55% accuracy, AUC 0.79)

Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons

In studies on spinal cord injuries, it helped animals recover function better and reduced the amount of tissue damage