But at the same time, the evidence behind the link between B12 and sleep isnt completely clear
Not only that, but often the form of B12 that these patients get is either cyanocobalamin or hydroxycobalamin
Individuals with B12 deficiency, which can occur due to dietary restrictions (e.g., vegan or vegetarian diets), gastrointestinal disorders affecting absorption, older age, or certain medical conditions that interfere with B12 absorption
Investigations that may be considered include: Blood tests to assess renal function, electrolytes (sodium, potassium, magnesium, calcium), glucose control (HbA1c), and thyroid function Creatine kinase (CK) if myopathy is suspected, particularly in patients taking statins Vitamin and mineral levels (vitamin D, vitamin B12) if deficiency is suspected Medication review to identify potential drug interactions or adverse effects Urgent medical attention is required if leg cramps are accompanied by: Severe pain with muscle swelling and warmth (possible deep vein thrombosis) contact NHS 111 or GP for same-day assessment Dark or cola-coloured urine (potential rhabdomyolysis, though extremely rare) Chest pain or severe breathlessness call 999 immediately Patients should be reassured that with appropriate assessment and management, leg cramps can usually be effectively controlled, allowing continuation of beneficial GLP-1 therapy under medical supervision
A 2010 cross-sectional analysis of meat-eaters, vegetarians and vegans found that 52% of the vegans, 7% of the vegetarians and 1 meat-eater had B12 deficiency
Possible Side Effects While MICC is typically well-tolerated, side effects may occur
