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TNF- is an extremely multifaceted intermediary, with structurally distinct domains that could function in either a damaging or a defensive way 16

doi: 10.1186/1477-7827-7-54 66

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

Such strategies would add more redox hot-spots for catalytic activity and thus enhance the activity of nanozymes

Folate is a generic term that describes the many different forms of Vitamin B9 such as folic acid, Folinic acid (5-formyl-tetrahydrofolic acid), Dihydrodfolate (DHF), tetrahydrofolate (THF), 5,10-methylenetetrahydrofolate (5, 10-MTHF) and 5-methyltetrahydrofolate (5-MTHF)

Concurrently, similar to treatment with the ferroptosis inducer RSL3, TST treatment caused cellular ROS accumulation, MDA overexpression, and GSH-PX depletion