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doi: 10.1182/blood-2006-09-044974 127 ChngWJKumarSVanwierSAhmannGPrice-TroskaTHendersonKet al

This supports the fact that higher enzyme expression level may lead to higher LC 50 values

The metal ions in the class of hard Lewis acids such as K + , Ca 2+ , Mg 2+ , Fe 3+

Conclusion and perspective Research on lactate metabolism and lactate-derived lactylation, as core drivers of cancer initiation and progression, is gradually changing our traditional perception of lactate as a metabolic waste product. This review systematically examines the basic mechanisms of lactate metabolism, its abnormal manifestations in tumor cells, and the multiple roles of lactate in the TME

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J Trace Elem Med Biol: Organ Soc Miner Trace Elem (GMS) 28:492494