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In contrast, the hypothetical strategy, outlined in the ICH guidelines [3] (also known as the trial product estimand in some clinical trials [29]), provides information on the pharmacological effect of the tested therapy under the assumption that intercurrent events will not occur

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Bells palsy is a condition that causes a temporary weakness or paralysis of the muscles in the face

Anti-inflammatory and cytoprotective effects were noted in a systematic review in 2024 and are also said to include attenuating oxidative stress and reinforcing gastrointestinal mucosal barriers during experimental injury

No statistical tests of comparisons were done for secondary and exploratory outcomes