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As a key regulator in Toll-like receptor (TLR) signaling, ATF2 undergoes p38 MAPK-dependent phosphorylation at Thr71 (107,166), through which it promotes the expression of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-, IL-6 and IL-1 (167-172)

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