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This antibody presence is thought to potentially elevate cytokine and chemokine levels, which is dependent on toll-like receptor (TLR)-2 signalling and causes NF-B activation (132, 133)

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Under physiological conditions, it supports synaptic plasticity [346], whereas under pathological states, such as during astrocytic necroptosis, proBDNF may exert neurotoxic effects and promote apoptotic signaling [349]

WADA category S5 is made up predominantly of diurectics including furosemide, hydrochlorothiazide, spironolactone, and acetazolamide

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