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SREBP2 is downregulated in GBM and is associated with poor prognosis

MS is typically diagnosed between the ages of 20 and 30 but it can also be diagnosed in children and in adults over the age of 30 (9, 73, 138)

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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis

Overall, non-presentation of some cell types in such models, the absence of blood flow, and a lack of metabolic and neurochemical coupling between the neuronal cells and the barrier components limit the implication of these models ( Dynamic BBB models were designed to overcome the disadvantages of the transwell models associated with the lack of shear stress and close contact of endothelial cells with neuroglia