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doi: 10.1006/bbrc.2001.5246 14 ObradovicMZafirovicSSoskicSStanimirovicJTrpkovicAJevremovicDet al

P.ZhouJ.BondyC.LupuF.BellvA

10.1016/j.biopha.2017.10.125 25

The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainably released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype

Activation of STING via cGAS-mediated recognition of double-stranded DNA results in phosphorylation and nuclear localization of IRF3, culminating in the production of type I interferons (IFN) and induction of local immune responses 17