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Taken together, our findings suggest that Cilengitide treatment can block tumor progression caused by POSTN-induced lipid accumulation under HFD, and the combination of AKT/ERK inhibitors is more effective, suggesting that this treatment approach is expected to become a new strategy for the targeted therapy of obesity-related CRC

Phytochemicals exhibit a wide variety of biological activities, target multiple pathways, and possess relatively low toxicity

elegans revealed extended life- and health-span independently of other mechanisms (Jenkins et al., 2020)

NACs multifaceted mechanisms of action (Figure 1) suggest a promising therapeutic role as an analgesic through glutathione synthesis enhancement, direct reactive oxygen species scavenging, inhibition of NF-B activation, modulation of neuroinflammatory pathways and mitochondrial protection

Akpoghelie PO, Edo GI, Akhayere E

GE Healthcare, Piscataway, NJ, USA) and imaged using a chemiluminescence imager (ChemiDoc