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Active tobacco smoking was a significant predictor of impaired LV and RV systolic function, with regard to EF (: 2.21 0.82%, 2.06 0.87%, P = 0.007, 0.019 respectively) as well as LV myocardial peak global longitudinal strain (GLS), peak global radial strain (GRS) and peak global circumferential strain (GCS) (: 0.86 0.30%, 2.52 0.99%, 1.05 0.32%, P = 0.004, 0.011, 0.001 respectively), both in univariate linear regression analyses and after further adjustment for matching parameters and possible confounders

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4) A 1998 Colorado State University study, published in the American Journal of Epidemiology, found a higher incidence of nasal tumors and cancer of the sinus in dogs living in a home with smokers, compared to those living in a smoke-free environment

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Use the 4 mg dose if you are one of those people that lights up within the first half an hour of waking up