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Frontiers in Endocrinology, 17

AOD9604 and 3-AR Knockout Research Research using 3-adrenergic receptor knockout mice established that AOD9604s chronic in vivo lipolytic actions are mediated in part by modulating the expression of 3-AR in adipose tissue a mechanism shared with intact hGH with the restoration of depressed 3-AR RNA levels in obese animals to lean-comparable levels identified as a key pathway of sustained lipolytic sensitisation

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Sample sizes (typically 36 biological replicates per group) were selected based on established standards in the field and our preliminary data, which indicated that this range was sufficient to detect biologically relevant effects

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