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Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

Drug Des Devel Ther 16:951972 Elliott W Jr, Guda MR, Asuthkar S, Teluguakula N, Prasad DV, Tsung AJ, Velpula KK (2021) PAD inhibitors as a potential treatment for SARS-CoV-2 immunothrombosis

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The peptides are beginning to interact with pineal cells and neural circuits, but the biological response takes time to manifest