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In addition, the anti-RA mechanism of ginsenoside Rg1 may be related to its anti-inflammatory effect by up-regulating peroxisome proliferators activated receptor- (PPAR-) and then inhibiting the NF-B signaling pathway (131)

[11] This may be due to a corresponding genetic predisposition to sequestering ferritin in the liver or due to an increased sensitivity to ethanol ingestion [11, 12]

Probiotics, prebiotics, and synbiotics are under clinical investigation as adjunct therapies to modulate gut-brain interactions and reduce systemic inflammation (Chan et al., 2022