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However, these inhibitors have limited effectiveness in individuals who develop resistance to PARP-1 inhibitors and in other malignancies, such as HCC (152)

Its enhanced version, two-dimensional difference gel electrophoresis (2D-DIGE), allows simultaneous quantitative comparison of multiple samples using distinct fluorescent labels, as demonstrated in CF serum proteomics investigations (Charro et al., 2011)

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A strength of this study was the use of human-derived tissues in vitro , providing greater clinical relevance