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Dimethyl fumarate (DMF) and its metabolite monomethyl fumarate (MMF) modulate some signaling proteins activity and intracellular concentration, such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), nuclear factor-kappa B (Nf-B), and cyclic adenosine monophosphate

10.3389/fphar.2014.00097 222 PiacentiniR.Li PumaD

Several studies have proved the clinical efficacy of Doxil, where improved tumor response rates and a favorable safety profile were observed compared to the conventional formulation of doxorubicin

J Proteome Res 15:31083117 Leonard MM, Bai Y, Serena G, Nickerson KP, Camhi S, Sturgeon C, Yan S, Fiorentino MR, Katz A, Nath B et al (2019) RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis

Additionally, when the aqueous layer is compromised, the use of artificial tear drops and secretagogues, such as diquafosol sodium eye drops, is recommended to maintain ocular surface lubrication and dilute inflammatory cytokine concentrations