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12 used a randomized crossover trial based on 40 cigarette smokers to show that HTPs use increased primary biomarkers (high-sensitivity C-reactive protein and white blood cell count) similarly to conventional cigarettes, and resulted in endothelial dysfunction and arterial stiffness to a less extent than cigarette smoke

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The research aims to identify concepts that are most powerful and effective, and aspects that can be improved to ensure the maximum effectiveness of the campaign