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Scher, G., Bente, D

Engineering of stimuli-responsive self-assembled biomimetic nanoparticles

Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines

Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is normal In other words, chronic injuries do not usually need one intervention

10.1042/BST20160129 32

13,28 In fact, the average time between seeking care and getting a fibromyalgia diagnosis has been reported to be 2.7 years