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S.et al (2016b)

Macho AP, Zipfel C

Interestingly, we found that both ferrostatin-1, a ferroptosis inhibitor 41 and 48c reduced the endogenous lipid peroxidation level in HK-2 cells and inhibition of IRE1 expression had similar but intermediate effects (Supplementary Fig

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This signaling cascade subsequently elevates ACSL4 expression, driving lipid peroxidation and ferroptosis through the ACSL4/lysophosphatidylcholine acyltransferase 3/arachidonate lipoxygenase 15 axis, as demonstrated in both in vitro and in vivo models of severe acute pancreatitis (114)