Invest Ophthalmol Vis Sci 2006
OS induces oxidative DNA damage, adversely affecting the balance between cell proliferation and programmed cell death leading to hyperplasia
Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO
Biochem J 470(2):207221
Increased coagulation times (altered platelet function), AV (Atrioventricular) block, Bradycardia (slow heart rate), Atrial arrhythmias (irregular heart beat), QT-interval prolongation (heart muscle takes longer than normal to recharge between beats), Ventricular tachycardia (including Torsade de Pointes abnormal heart rhythm that can lead to sudden cardiac death ), Angioedema (swelling), Hyponatremia, Hyperglycemia, Serotonin syndrome, Extrapyramidal symptoms:, Akathisia (inner restlessness accompanied by mental distress and an inability to sit still), Decreased libido , Dystonia (twisting and repetitive movements or abnormal fixed postures), Oculogyric crisis (prolonged involuntary upward deviation of the eyes), Psychosis (difficulty determining what is real and what is not real), Paroniria (excess of morbid dreams and nightmares), Photosensitivity skin reaction and other severe cutaneous reactions, which potentially can be fatal , such as Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), Vasculitis (group of disorders that destroy blood vessels by inflammation), Pancreatitis, Optic neuritis, Tachycardia (increased heart rate), Tinnitus (ringing in the ears), Hypothyroidism, Mydriasis (dilated pupils), Blurred vision, Hematochezia ( passage of fresh blood through the anus ), Melena (dark black, tarry feces), Rectal hemorrhage, Severe liver events (including hepatitis, jaundice, liver failure with some fatal outcomes ), Aplastic anemia (body fails to produce blood cells in sufficient numbers), Pancytopenia, Leukopenia, Thrombocytopenia, Lupus-like syndrome , Serum sickness, Gynecomastia (abnormal non-cancerous enlargement of one or both breasts in males), Cerebrovascular spasm (including reversible cerebral vasoconstriction syndrome and CallFleming syndrome), Angle-Closure Glaucoma (damage to the optic nerve and potential vision loss ), Activation of mania/hypomania for bipolar patients, Nausea, Diarrhea/loose stool, Tremor, Dyspepsia (indigestion), Decreased appetite, Hyperhidrosis (abnormally increased sweating), Ejaculation failure , Enuresis (bed-wetting), Hyperprolactinemia (abnormally high levels of prolactin in the blood), Menstrual irregularities, Pulmonary hypertension (increased blood pressure in the arteries of the lungs), Acute renal (kidney) failure , SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion), Blindness , Cataract (cloudy area in the lens of the eye that leads to a decrease in vision), Agranulocytosis (severe and dangerous lowered white blood cell count), Edema, Gait disturbance, Irritability, Pyrexia (fever), Elevated liver enzymes, Anaphylaxis, Diabetes mellitus, Hypercholesterolemia (high cholesterol), Hypoglycemia (low blood sugar), Increased appetite, Arthralgia (joint pain), Muscle spasms, Tightness, Twitching, Ataxia (lack of voluntary coordination of muscle movements), Coma, Decreased alertness, Hypoesthesia (numbness), Hematuria (presence of blood or red blood cells in the urine), Galactorrhea (spontaneous flow of milk from the breast), Vaginal hemorrhage, Priapism (penis remains erect for hours in the absence of stimulation or after stimulation has ended), Alopecia (balness), Dermatitis bullous (inflammatory lesion of the skin with the formation of fluid), Pruritus (itchiness), Purpura (red/purple spots), Convulsion, Lethargy (state of tiredness, sleepiness, weariness, fatigue, sluggishness or lack of energy), Psychomotor hyperactivity ( mood disorders ), Syncope (fainting), Aggression, Bruxism (excessive teeth grinding or jaw clenching), Confusional state, Euphoric mood, Hallucination, Bronchospasm (sudden constriction of the muscles in the walls of the bronchioles), Epistaxis (nosebleed), Yawning, Cold sweat, Dermatitis, Hemorrhage (bleeding from a damaged blood vessel), Hypertension (high blood pressure), Vasodilation (widening of blood vessels), Erythematous (skin redness), Follicular/maculopapular rash, Urticaria (hives)
R., de Oliveira, C
