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Detailed documentation is provided on the FinnGen website ( Sample independence Participant overlap in samples used to estimate genetic associations between exposures and outcomes can increase weak instrument bias (WIB) in MR analyses 60,83 , but to a lesser extent with large biobank samples (including UKB and deCODE)

Given the small sample sizes and non-normality of the residuals we used LMM permutation tests to evaluate the strength of the associations

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