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10.1371/journal.pone.0210248 115 KipplerM.OskarssonA

doi:10.1007/s00249-003-0348-1

However, the association between high blood levels of TMAO and atherosclerosis was not observed in the Coronary Artery Risk Development in Young Adults Study (CARDIA) (52) It is not yet clear whether concentrations of choline, betaine, and/or TMAO in the blood can predict the risk for cardiovascular disease

doi: 10.3389/fimmu.2016.00096 69 JohanssonMABjrkanderSForsbergMMQaziKRCeladesMSBittmannJet al

Figure 4 shows activated CD8+ cytotoxic T lymphocytes recognizing a bacterial peptide presented by HLA-B27 (derived from Immunopaedia case study: 14 year old with severe hip pain) This causes liberation of cytotoxic granules (perforin and granzymes) from the CD8+ T cell which then cause lysis and apoptosis of infected target cells Watch a video of the different killing mechanisms, including CD8 CTL Reproduced with permission from Bellanti, JA (Ed)