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In this context, it is still debated whether inflammation directly causes neurodegeneration or the neuronal loss induces glia activation, generating a positive feedback loop in which inflammatory cytokines and neurotoxic molecules released by activated glial cells promote both neurodegeneration and self-perpetuating inflammatory response (Figure 1B)

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Unlike in humans, LCA is normally only minimally present in rodents 77 , and exogenous LCA feeding can have serious detrimental consequences for mice, including hepatobiliary injury leading to eventual death 78

Vernizzi L, Paiardi C, Licata G et al (2020) Glutamine synthetase 1 increases autophagy lysosomal degradation of mutant huntingtin aggregates in neurons, ameliorating motility in a drosophila model for Huntingtons disease