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Secreted CBS and CSE have been proposed to contribute for the maintenance of homocysteine levels in the plasma

Evaluation of these three biomarkers was performed in urine samples from 24 control patients, one severe APAP overdose patient and 10 additional patients suspected of drug-induced acute liver injury (ALI) where eight of the 10 ALI patients were linked to APAP ingestion

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It has also been observed that the addition of exogenous MOTS-c increases the level of myocardial MOTS-c, which activates AMPK (33)