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All these suggest that hepatocytes may downregulate the expression of HNF4 in an injured liver, which promote the EMT of hepatocytes and contribute to the fibrosis process (100)

Bone marrow-specific TGF-1 KO or the use of TGF-R1 inhibitors significantly improves liver regeneration after AILI

Despite its theoretical appeal for treating insomnia (Choi et al., 2022), especially as an age-related intervention (Xu et al., 2020), the efficacy, optimal dosing, and pharmaceutical formulations of melatonin remain under-researched, indicating a need for further scientific validation to establish its clinical utility (Poza et al., 2022)

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