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Mitochondria play a crucial role in these metabolic alterations of cancer [7] and in some circumstances, their dysfunction can predispose to cancer

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But its backed by gene expression studies showing that GHK-Cu modulates over 4,000 human genes, with a significant portion involved in tissue remodeling, antioxidant defense, and stem cell function [3]

At present, several chemically diverse families have emerged as GSK-3 inhibitors 16 , including peptides 17 , metal ions 18 , and diverse small heterocycles 19 , and the development of GSK-3 inhibitor recently became a potential therapy for AD

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Acta 70 , 221230 (1963)