In support of this hypothesis, diminished expression of STIM and Orai proteins has been shown to be at the origin of decreased SOCE and increased resistance to oxidative damage in HT22 cells (Rao et al., 2013)
These proteins catalyze the conversion of hydrogen peroxide (H 2 O 2 ) and organic or lipid hydroperoxides into water or alcohols, using glutathione (GSH) or thioredoxin (Trx) as electron donors (Iqbal et al., 2006
doi: 10.1200/JCO.2009.23.8329
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