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Another study showed that DFO could suppress excessive collagenase-mediated type II collagen cleavage and protease, production of cytokine, and COL10A1 expression while upregulating adenosine monophosphate-activated protein kinase and Krebs cycle genes in human osteoarthritic cartilage [125]

Precision microbiome modulation with discrete dietary fiber structures directs short-chain fatty acid production

Thromb Haemost 109:10991107

This strategy promotes a paradigm shift from uniform dosing to biomarker-guided personalized therapy, providing a feasible pathway for optimizing the precise application of L-citrulline in male reproductive health