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Because age-related cognitive decline has been linked to free radical-induced oxidative damage in the brain (159, 160), antioxidant supplements might help protect against cognitive aging

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Consequently, the purpose of the underlying review is to elucidate the potential molecular mechanisms of MTX-induced intestinal injury and study the protective strategies involved in the amelioration of this injury

55,56,57 Recently, the first gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology has been approved for marketing, 58 resulting in revolutionary changes in NADs development