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These detailed cascades, while well-documented in the cited literature, are proposed as hypothetical frameworks to explain the functional consequences of the target downregulation we observed, and they require direct experimental confirmation in the context of palmatine treatment

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mansoni were administered 6 mg/kg AF twice daily for 9 d, which is a safe dose for healthy mice [46], beginning 7 wk after infection (when adult worms are present in the mesenteric venules) followed by a 1 wk rest

Administration of coumestrol and/or dimethyl sulfoxide affects vaginal epithelium and sex hormones in female dogs