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Despite the potential strength of using specific aspartame intake in this analysis, the unclear outcome definition meant that the earlier analysis of NHANES data was considered to be more informative, although both analyses were consistent in not finding strong evidence linking aspartame or ASB intake with cancer mortality.] During a median follow-up of 27.7 years, 135 093 CPS-II participants died from cancer (25.9% of all deaths) (McCullough et al., 2022)

placebo at 68 weeks in 667 patients with a mean age of 50 years, mostly females, with a mean BMI of 37.5 kg/m 2 and dysglycemia in 8% participants (BW reduction 15.1% vs

Frequency: 2 mg: Once weekly

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doi: 10.1186/s12967-023-04458-z 266 JungDWCheZMKimJKimKKimKYWilliamsDet al