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Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

At the same time, limitations remain obvious: clinical data are still insufficient, most conclusions are based on experimental models, and questions of long-term safety, application protocols, and effectiveness at later stages of degeneration require additional research

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Thiamine works as a co-enzyme for complexes including enzymes essential for intracellular glucose metabolism, such as transketolase, pyruvate dehydrogenase (PDH), and -ketoglutarate dehydrogenase

Neurons almost exclusively express the MCT2 isoform, which possesses a high affinity for BHB released from endothelial cells and astrocytes

BPC-157 component In small human inflammatory bowel disease trials referenced in the Sikiric review (PMID 21548867), no toxicity at oral doses studied was reported