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A study by Zhang et al

Shikonin targets TrxR and induces oxidative stress to promote apoptosis in gefitinib-resistant non-small cell lung cancer cells, with decreases in NADPH and the GSH/GSSG ratio [163]

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As expected, M1 high tumors demonstrated significantly higher favorable immune activity, such as, Lymphocyte Infiltration Signature Score, TIL Regional Fraction Score and IFN-gamma Response in TCGA cohort (Fig

Glutathione is also important for the function of various immune cells and therefore strengthens the body's defenses

Statistics and reproducibility The students t test was used to compare the differences between two independent groups, and one-way or two-way analysis of variance (ANOVA) was used for comparisons among three or more groups