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There are no published, peer-reviewed human clinical trials of injectable or subcutaneous GHK-Cu establishing efficacy or safety for any outcome

Kosmas CE, Bousvarou MD, Kostara CE, Papakonstantinou EJ, Salamou E, Guzman E

2017;140(619622):e616

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Nevertheless, there are few animal studies and in vitro studies demonstrating the role of natural extracts like irradiated green tea polyphenol, [19] proanthocyanidin-rich extract from grape seeds, [20] ellagic acid-rich pomegranate extract, [21] and coumarin extracts from the plant Angelica dahurica , [22] in inhibiting melanogenesis resulting in skin whitening thereby recommending these agents as oral preparations for skin whitening