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Even though meta-analyses found no psychiatric side-effects, such as depression and bad mood, derived from smoking cessation 47,48 among general smoking quitters, some studies have detected an increased depression risk among those who attempt to quit unsuccessfully 49 and somatic adverse reactions among individuals with nicotine replacement therapy 50

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This is in agreement with the observation that the Chlamydiaceae have undergone evolutionary selection for proteins with lower-than-average tryptophan content (Down-Trp selection), which may operate during the persistent state triggered by tryptophan starvation (Bonner et al., C

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"Canada bans fruit-flavored cigarettes"