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Here are some of the ways estrogen affects your body: regulates your menstrual cycle supports fertility and helps babies develop during pregnancy keeps your vaginal tissue healthy, which improves sexual health supports bone density boosts cognitive function and helps you focus improves blood sugar, cholesterol, and blood flow helps produce collagen for healthier skin improves muscle mass Its no wonder that as estrogen levels fluctuate throughout midlife, it can feel like every part of your body is changing