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Abbreviations RA: Rheumatoid arthritis DSP: Dexamethasone sodium phosphate ChS: Chondroitin sulfate Gel: Nanogel EE: Encapsulation efficiency LE: Loading efficiency PDI: Polydispersity index LPS: Lipopolysaccharides CCK-8: Cell counting kit-8 RTCC: Rat cartilage cells CIA: Collagen-induced arthritis ELVIS: Extravasation across leaky vasculature followed by sequestration by inflammatory cells TNF-: Tumor necrosis factor alpha IL-1: Interleukin-1 IL-6: Interleukin-6 IL-10: Interleukin-10 CLSM: Confocal laser scanning microscopy H&E: Hematoxylin-eosin TB: Toluidine blue SO: Safranin O Micro-CT: Microcomputed tomography BMD: Bone mineral density BS/BV: bone surface area to bone volume BV/TV: Bone volume to the total volume Tb.N: Trabecular number Tb.Th: Trabecular bone thickness Tb.Sp: Trabecular separation ALT: Alanine aminotransferase AST: Aspartate aminotransferase CREA: Creatinine UREA: Urea References Wu D, Luo Y, Li T, Zhao X, Lv T, Fang G, Ou P, Li H, Luo X, Huang A, Pang Y

While they are frequently mentioned together, they differ significantly in origin, structure, and scientific focus

Therefore, it is hypothesized that systemic (IV or IM) stem cell therapy may offer better efficacy in moderate-to-severe AA by addressing systemic immune dysregulation

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Orally, it undergoes rapid intestinal absorption and metabolism by the liver, which directs most of the cysteine released toward GSH synthesis