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While some retrospective studies suggest that metformin may confer a survival benefit for diabetic patients with solid tumors, including PDAC, randomized controlled trials have not found significant benefits for PDAC patients when metformin is combined with gemcitabine [109, 113]

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however, after 2 and 7 days, it increased to the value of the control (Kamendulis et al

Statistics All statistical data were generated using the GraphPad Prism software package (GraphPad Software version 8 Inc., La Jolla, CA, USA)

All animal procedures were performed by following the Institutional Animal Care and Use Committee (IACUC) approved protocols

The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials