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16 Likewise, the GLS gene, located in chromosome 2, encodes two splice variants with high activity and low substrate affinity, kidney-type glutaminase (KGA, long transcript isoform) and glutaminase C (GAC, short transcript isoform), which are mainly expressed in the kidney under healthy conditions

Kvasyuk El, Mikhailopulo IA, Suhadolnik RJ, Henderson EE, Muto NF, lacono KT, Homon J, Pfleiderer W: Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives

[Google Scholar] 66.Sinha D., Bonner T.I., Bhat N.R., Matsuda L.A

A similar mode of action is also present with zanidatamab, a bi-specific antibody targeting the extracellular juxtamembrane domain and the dimerization domain of HER2

doi: 10.4239/wjd.v12.i10.1693