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Elsayed EF, Reilly RF
Mujdat Zeybel, MD, NIHR Nottingham Biomedical Research Centre This study demonstrated CMCS supplementation significantly decreased liver fat, improved liver function, and decreased liver inflammation in NAFLD patients, suggesting CMCS may be an effective therapeutic strategy for NAFLD, No drugs have been approved to treat NAFLD, and effective treatment options with long-term safety are urgently required. The combined metabolic cofactor supplementation (CMCS) regimen developed by the Nottingham group and used in this trial consists of: 1g nicotinamide riboside (NR), which raises mitochondrial NAD+ levels, and boosts fat metabolism 3.73g L-carnitine tartrate, which promotes transport of fat into the mitochondria 12.35g L-serine, which increases glutathione synthesis 2.55g N acetyl-L-cysteine (NAC), which also promotes glutathione production and reduces oxidative stress A total of 31 patients with MRI-confirmed non-alcoholic steatosis were randomized to either placebo (N=11) or the CMCS combination (N= 20)
The data is limited, and the use of L-arginine in patients with a history of heart attack or kidney disease is generally contraindicated, since L-arginine can actually increase the risk for complications in these populations. Under the guidance of your doctor, dietary strategies, along with medication, will likely also be implemented to help lower blood pressure
The differences in regional LV function were confirmed by consistent increases in longitudinal and/or circumferential peak systolic strain in the basal anterior, anterolateral and inferolateral segments, and reductions in deformation in the mid inferior segment regardless of the presence of significant MR
