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This could trigger specific signal cascades [16] or release cytolytic lysophospholipids capable of disrupting the integrity of the host cell membrane [17, 18]

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Furthermore, HF leads to endothelial dysfunction in various tissues, including skeletal muscles, as a result of reduced NO production by endothelial NO synthase [18]

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While not typically causing classical HCU, these variants can worsen biochemical imbalances in genetically predisposed individuals (2729)