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Insulin-like growth factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes. Oxidative Medicine and Cellular Longevity 2017 (2017)

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The authors described these molecules as unknown unknowns that may have confounded previous disease models

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Nonetheless, their long-term disease-modifying potential remains limited, in part due to the complexity of underlying pathophysiological processes and compensatory mechanisms within the human brain