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Li XY, Men WW, Zhu H, Lei JF, Zuo FX, Wang ZJ, et al

doi:10.1027/0269-8803/a000014

Factors that may contribute to interstitial cystitis (IC): Inflammation and mast cell activation Inflammation can release chemicals that disrupt the integrity of the bladders epithelial surface leading to mast cell activation and ultimately giving rise to pain and voiding dysfunction